Mitochondria are often referred to as the powerhouses of the cell. Their main function is to generate the energy necessary to power cells. But, there is more to mitochondria than energy production.
Present in nearly all types of human cell, mitochondria are vital to our survival. They generate the majority of our adenosine triphosphate (ATP), the energy currency of the cell.
Mitochondria are also involved in other tasks, such as signaling between cells and cell death, otherwise known as apoptosis.
In this article, we will look at how mitochondria work, what they look like, and explain what happens when they stop doing their job correctly.
Mitochondria are small, often between 0.75 and 3 micrometers and are not visible under the microscope unless they are stained.
Unlike other organelles (miniature organs within the cell), they have two membranes, an outer one and an inner one. Each membrane has different functions.
Mitochondria are split into different compartments or regions, each of which carries out distinct roles.
Some of the major regions include the:
Outer membrane: Small molecules can pass freely through the outer membrane. This outer portion includes proteins called porins, which form channels that allow proteins to cross. The outer membrane also hosts a number of enzymes with a wide variety of functions.
Intermembrane space: This is the area between the inner and outer membranes.
Inner membrane: This membrane holds proteins that have several roles. Because there are no porins in the inner membrane, it is impermeable to most molecules. Molecules can only cross the inner membrane in special membrane transporters. The inner membrane is where most ATP is created.
Cristae: These are the folds of the inner membrane. They increase the surface area of the membrane, therefore increasing the space available for chemical reactions.
Matrix: This is the space within the inner membrane. Containing hundreds of enzymes, it is important in the production of ATP. Mitochondrial DNA is housed here (see below).
Different cell types have different numbers of mitochondria. For instance, mature red blood cells have none at all, whereas liver cells can have more than 2,000. Cells with a high demand for energy tend to have greater numbers of mitochondria. Around 40 percent of the cytoplasm in heart muscle cells is taken up by mitochondria.
Although mitochondria are often drawn as oval-shaped organelles, they are constantly dividing (fission) and bonding together (fusion). So, in reality, these organelles are linked together in ever-changing networks.
Also, in sperm cells, the mitochondria are spiraled in the midpiece and provide energy for tail motion.
Although most of our DNA is kept in the nucleus of each cell, mitochondria have their own set of DNA. Interestingly, mitochondrial DNA (mtDNA) is more similar to bacterial DNA.
The mtDNA holds the instructions for
The human genome stored in the nuclei of our cells contains around 3.3 billion base pairs, whereas mtDNA consists of
During reproduction, half of a child’s DNA comes from their father and half from their mother. However, the child always receives their mtDNA from their mother. Because of this, mtDNA has proven very useful for tracing genetic lines.
For instance, mtDNA analyses have concluded that humans may have originated in Africa relatively recently, around 200,000 years ago, descended from a common ancestor, known as
Although the best-known role of mitochondria is energy production, they carry out other important tasks as well.
In fact, only about 3 percent of the genes needed to make a mitochondrion go into its energy production equipment. The vast majority are involved in other jobs that are specific to the cell type where they are found.
Below, we cover a few of the roles of the mitochondria:
ATP, a complex organic chemical found in all forms of life, is often referred to as the molecular unit of currency because it powers metabolic processes. Most ATP is produced in mitochondria through a series of reactions, known as the citric acid cycle or the Krebs cycle.
Energy production mostly takes place on the folds or cristae of the inner membrane.
Mitochondria convert chemical energy from the food we eat into an energy form that the cell can use. This process is called oxidative phosphorylation.
The Krebs cycle produces a chemical called NADH. NADH is used by enzymes embedded in the cristae to produce ATP. In molecules of ATP, energy is stored in the form of chemical bonds. When these chemical bonds are broken, the energy can be used.
Cell death, also called apoptosis, is an essential part of life. As cells become old or broken, they are cleared away and destroyed. Mitochondria help decide which cells are destroyed.
Mitochondria release cytochrome C, which activates caspase, one of the chief enzymes involved in destroying cells during apoptosis.
Because certain diseases, such as cancer, involve a breakdown in normal apoptosis, mitochondria are thought to play a role in the disease.
Calcium is vital for a number of cellular processes. For instance, releasing calcium back into a cell can initiate the release of a neurotransmitter from a nerve cell or hormones from endocrine cells. Calcium is also necessary for muscle function, fertilization, and blood clotting, among other things.
Because calcium is so critical, the cell regulates it tightly. Mitochondria play a part in this by quickly absorbing calcium ions and holding them until they are needed.
Other roles for calcium in the cell include regulating cellular metabolism, steroid synthesis, and
When we are cold, we shiver to keep warm. But the body can also generate heat in other ways, one of which is by using a tissue called brown fat.
During a process called
The DNA within mitochondria is more susceptible to damage than the rest of the genome.
This is because free radicals, which can cause damage to DNA, are produced during ATP synthesis.
Also, mitochondria lack the same protective mechanisms found in the nucleus of the cell.
However, the majority of mitochondrial diseases are due to mutations in nuclear DNA that affect products that end up in the mitochondria. These mutations can either be inherited or spontaneous.
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