The Products Evaluation Platform is committed to ensuring the effectiveness and safety of both raw materials and finished products. This is achieved through a variety of testing methods, including physical and chemical tests, cell assays, zebrafish assays, and chick chorioallantoic membrane assays. These methods are applied across the product's lifecycle to continuously monitor and enhance product quality.
The Clinical Research Platform is centered around assessing the effects of anti-aging interventions on the human body. This encompasses studies on pharmacokinetics, pharmacodynamics, tolerance, and safety, conducted through randomized, placebo-controlled, parallel-design trials. The outcomes of these clinical trials are fundamental in supporting the development of anti-aging products, whether as medicines or dietary supplements. To date, CELFULL and its partners have successfully conducted two clinical trials.
Effect of NMN and exercise on middle-aged and elderly people
Randomized double-blind, placebo- controlled trial
Real-world NAD+ disparity and NAD+dynamics
The full name of NAD+is oxidized nicotinamide adenine dinucleotide. Because NAD+plays an important role in immune regulation, energy metabolism and other processes, its metabolic state is closely related to many symptoms of COVID-19 sequelae.
Hebe Lab is committed to building a global anti-aging integration technology platform. Leveraging existing aging intervention technology, the lab conducts real-world research to develop systematic anti-aging solutions. The ultimate goal is to reverse physiological aging, restoring the vitality of the 60s to that of the 30s.
Technique Foundation of Aging Intervention
Real-world Research of Aging Intervention
Extention Research of Aging Intervention
The importance of NAD+ in maintaining youth and health has been extensively documented by research groups worldwide. Assessing NAD+ levels and dynamics from mitochondria, cells, tissues, organs, and human serum is pivotal for further exploring NAD+ metabolism. Quantifying these levels and understanding their relationship with aging enables precise and personalized aging intervention through NAD+ regulation.
Human NAD+ levels are detected using a semi-synthetic NAD+ biosensor, requiring only 5 milliliters of fingertip blood. This biosensor is suitable for various biological samples like blood, saliva, and cell lysate. Its detection sensitivity is comparable to LC-MS, the gold standard for NAD+ concentration detection, but offers more convenient sample preparation, quicker detection, and lower cost. The NAD+ biosensor can be integrated into either a tabletop or a portable device, and its research has been published in notable journals like Science and Nature Metabolism
The principle of bioluminescence resonance energy transfer (BRET) is employed for NAD+ concentration detection. When the NAD+ response protein binds to an NAD+ molecule, it changes from an 'open' to a 'closed' state. This change facilitates a closer proximity between the energy transfer donor and receptor, leading to a more efficient resonance energy transfer. The change in resonance energy transfer efficiency, caused by the NAD+ molecule, is manifested as a shift in the emission intensity ratio of the probe's donor and receptor, indicating the NAD+ concentration in the system.
